Table 5. Amblyomma americanum tick saliva protein categories that are conserved in other tick saliva proteomes at 70% identity.
| Classification | I. scapularis | H. longicornis | D. andersoni | R. microplus | O. moubata | R. sanguinues |
|---|---|---|---|---|---|---|
| Cytoskeletal | 36 | 27 | 19 | 12 | 3 | 0 |
| Detoxification | 13 | 9 | 9 | 5 | 0 | 2 |
| Extracellular matrix | 3 | 6 | 9 | 3 | 0 | 1 |
| Glycine rich | 5 | 4 | 4 | 4 | 0 | 0 |
| Immune related | 4 | 3 | 3 | 4 | 1 | 1 |
| Metabolism, amino acids | 4 | 1 | 0 | 0 | 0 | 0 |
| Metaolism, carbohydrates | 4 | 3 | 6 | 1 | 1 | 0 |
| Metabolim, energy | 20 | 11 | 12 | 0 | 4 | 0 |
| Metabolism, lipids | 2 | 1 | 3 | 4 | 0 | 0 |
| Metabolism, nucleic acids | 11 | 9 | 1 | 0 | 2 | 0 |
| Nuclear regulation | 6 | 5 | 6 | 4 | 0 | 0 |
| Protein modification | 16 | 14 | 8 | 9 | 7 | 0 |
| Protease | 6 | 6 | 8 | 3 | 0 | 0 |
| Proteosome machinery | 7 | 6 | 5 | 0 | 0 | 6 |
| Protein synthesis | 4 | 2 | 3 | 2 | 0 | 0 |
| Secreted saliva proteins | 5 | 6 | 22 | 14 | 0 | 0 |
| Lipocalin | 0 | 0 | 0 | 4 | 0 | 0 |
| Protease Inhibitors | 5 | 14 | 10 | 11 | 1 | 1 |
| Signal transduction | 6 | 3 | 6 | 1 | 1 | 0 |
| Heme/Iron binding | 1 | 7 | 2 | 9 | 2 | 0 |
| Transcription machinery | 2 | 0 | 1 | 1 | 0 | 0 |
| Transporters/ receptors | 3 | 1 | 0 | 1 | 0 | 0 |
| Total Protein Matches | 163 | 138 | 137 | 92 | 22 | 11 |