TABLE 3.

Guyatt’s Responsiveness Statistics for Changes in Huntington Disease Health-Related Quality of Life

	Self-Reported Changes in Physical Health (From Anchor Items)
	Baseline to 12 Months						Baseline to 24 Months
	No Change in Health		Declines in Health		Improvement in Health		No Change in Health		Declines in Health		Improvement in Health
	N	SRM	N	SRM	N	SRM	N	SRM	N	SRM	N	SRM
Chorea CAT	223	0.10	74	0.26	24	−0.30	139	0.20	78	0.30	22	0.15
Chorea SF	220	0.06	73	0.20	24	−0.19	137	0.21	77	0.44	22	0.27
Speech Difficulties CAT	225	0.05	76	0.21	21	−0.24	142	0.14	83	0.28	18	−0.02
Speech Difficulties SF	224	0.00	75	0.18	21	−0.35	144	0.12	81	0.26	18	−0.15
Swallowing Difficulties CAT	239	0.03	64	0.58	21	−0.22	145	0.09	78	0.61	20	0.10
Swallowing Difficulties SF	241	0.08	61	0.64	21	0.01	145	0.19	76	0.71	20	0.40
Upper Extremities CATa	210	−0.11	80	−0.46	33	0.15	127	−0.36	90	−0.47	28	−0.12
Upper Extremities SFa	211	−0.12	80	−0.44	33	−0.02	128	−0.17	90	−0.43	28	−0.06
Lower Extremities CATa	197	−0.14	63	−0.34	63	0.05	125	−0.29	66	−0.58	56	−0.06
Lower Extremities SFa	197	−0.13	63	−0.40	63	−0.06	125	−0.26	66	−0.46	56	0.08
	Clinician-Rated Changes in Function (From TFC)
	Baseline to 12 Months						Baseline to 24 Months
	No Change in Health		Declines in Health		Improvement in Health		No Change in Health		Declines in Health		Improvement in Health
	N	SRM	N	SRM	N	SRM	N	SRM	N	SRM	N	SRM
Chorea CAT	238	0.06	68	0.22	23	0.20	216	0.24	45	0.31	28	−0.28
Chorea SF	234	0.04	68	0.10	23	0.07	214	0.30	44	0.46	27	0.00
Speech Difficulties CAT	236	0.01	68	0.17	23	−0.06	216	0.16	44	0.32	28	0.01
Speech Difficulties SF	235	−0.03	68	0.14	23	−0.09	216	0.12	45	0.37	27	−0.11
Swallowing Difficulties CAT	236	0.12	68	0.11	23	−0.25	216	0.17	44	0.53	28	0.33
Swallowing Difficulties SF	236	0.15	69	0.30	22	−0.15	215	0.33	45	0.54	26	0.42
Upper Extremities CATa	233	−0.05	66	−0.51	23	−0.04	215	−0.27	41	−0.75	26	−0.49
Upper Extremities SFa	235	−0.15	66	−0.41	23	0.24	217	−0.25	42	−0.42	26	0.11
Lower Extremities CATa	233	−0.07	66	−0.39	23	0.07	215	−0.24	41	−0.53	26	−0.21
Lower Extremities SFa	234	−0.10	66	−0.44	23	−0.01	217	−0.28	42	−0.48	26	−0.07

Bold indicates effects size magnitudes that are consistent with the proposed hypotheses.

^aHigher scores indicate better Huntington Disease Health-Related Quality of Life.

SRM, standardized response mean; TFC, Unified Huntington Disease Rating Scale Total Functional Capacity; CAT, Computer Adaptive Test; SF, Short Form.