Fig 5. Calcium binding and CaM conformational changes in response to calcium input frequencies.
Calcium binding CaM was followed during simulations using trains of 300 spikes at different frequencies. Plots show calcium saturation levels at the C and N lobe and the corresponding CaM conformational changes, with CaM on its own, or in the presence of Ng. Red dots represent the end of calcium stimulation. [CaM]tot = 40 μM, [Ng]tot = 40 μM, basal [Ca] = 0.08 μM.