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. 2020 Feb 12;16(2):e1006991. doi: 10.1371/journal.pcbi.1006991

Fig 5. Calcium binding and CaM conformational changes in response to calcium input frequencies.

Fig 5

Calcium binding CaM was followed during simulations using trains of 300 spikes at different frequencies. Plots show calcium saturation levels at the C and N lobe and the corresponding CaM conformational changes, with CaM on its own, or in the presence of Ng. Red dots represent the end of calcium stimulation. [CaM]tot = 40 μM, [Ng]tot = 40 μM, basal [Ca] = 0.08 μM.