Fig 12. Ng concentration affects synaptic plasticity.

Computational models with various Ng concentrations were stimulated by 300 calcium spikes at various frequencies. The concentrations of proteins, except Ng, were listed in Table 1 and remain unchanged. In particular, the concentration of CaM is 40 μM. The activated areas of CaMKII and CaN were calculated and their net effects on AMPA receptor phosphorylation were calculated as described in Fig 7, and plotted as a function of calcium spike frequency.