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. 2020 Feb 25;9:e49917. doi: 10.7554/eLife.49917

Figure 6. DAF-2B overexpression extends lifespan.

Figure 6.

(A) The daf-2(e1368) hypomorphic mutation confers lifespan extension. Overexpression of DAF-2B from the native daf-2 promoter (B), in the nervous system (C), in the hypodermis (D), in the muscle (E) or in the intestine (F) extends lifespan in wild type N2 animals. Genetic deletion of daf-2b (G) and daf-2c (H) has no effect on lifespan in wild type N2 animals. Log Rank test ns – not significant, ***p<0.001. Lifespan data are representative of n = 2 biological replicates for DAF-2B overexpressers and n = 3 for deletion strains. Summary data for all replicates are presented in Supplementary file 1.