Table 1. Clinical and laboratory characteristics of patients with allopurinol-induced SCARs (all had DRESS syndrome).
| Patient | Gender/age (years) | Allopurinol dose (mg/d)/duration (d) | Sx.a (d) | Underlying disease | HLA-B | LAT |
|---|---|---|---|---|---|---|
| 1 | M/63 | 100/14 | 7 | Hypertension Gout |
*13:02, *58:01 | - |
| 2 | F/71 | 200/30 | 24 | Hypertension ESRD Gout |
*48:01, *58:01 | - |
| 3 | M/22 | 200/2 | 20 | DM Tuberculosis Gout |
*44:03, *58:01 | + |
SCARs, severe cutaneous adverse reactions; DRESS, drug reaction with eosinophilia and systemic symptoms; HLA, human leukocyte antigen; LAT, lymphocyte activation test; ESRD, end-stage renal disease; DM, diabetes mellitus. aSymptom onset after starting the drug.