Table 1. Normalized Cmin and Cmax by EC50 at each dose scenario.
| Dose (mg) | Single dose | Multiple Doses | ||||
|---|---|---|---|---|---|---|
| Cmax/EC50 (Range) * | Cmin,ss/EC50 (Range)† | Cmax,ss/EC50 (Range)‡ | ||||
| 12.5 | 0.11 | (0.10 - 0.11) | 0.16 | (0.14 - 0.18) | 0.25 | (0.23 - 0.26) |
| 25 | 0.21 | (0.20 - 0.23) | 0.32 | (0.28 - 0.35) | 0.49 | (0.46 - 0.53) |
| 50 | 0.42 | (0.39 - 0.45) | 0.63 | (0.57 - 0.71) | 0.99 | (0.92 - 1.1) |
| 100 | 0.85 | (0.78 - 0.91) | 1.3 | (1.1 - 1.4) | 2.0 | (1.9 - 2.1) |
| 200 | 1.7 | (1.5 - 1.8) | 2.5 | (2.3 - 2.8) | 3.9 | (3.7 - 4.2) |
| 400 | 3.4 | (3.1 - 3.6) | 5.1 | (4.6 - 5.6) | 7.9 | (7.4 - 8.4) |
| 800 | 6.8 | (6.3 - 7.2) | 10 | (9.1 - 11) | 16 | (15 - 17) |
*, the median values and ranges of normalized maximum concentration for single-dose study, †, the median values and ranges of normalized minimum concentration for multiple-dose study, ‡, the median values and ranges of normalized maximum concentration for multiple-dose study.