Table 4. Calculated pharmacokinetic parameters of sumatriptan after oral administration of 50-mg to healthy nine female and three male volunteers.
| Parameters | Women | Men | P value |
|---|---|---|---|
| AUC0–12 (ng h/mL) | 186±39 | 119±19 | 0.018 |
| AUC0-∞ (ng h/mL) | 194±42 | 125±19 | 0.023 |
| AUC0–∞/bw (ng h/mL × 106)a | 202±37 | 188±38 | 0.597 |
| Cmax (ng/mL) | 42.0±7.2 | 26.8±3.3 | 0.006 |
| Cmax/bw (ng/mL × 106)a | 43.8±7.1 | 40.0±1.3 | 0.391 |
| Tmax (h) | 2.0±0.9 | 2.0±1.0 | 1.000 |
| T1/2 (h) | 2.6±1.3 | 2.6±1.0 | 0.933 |
*Data are shown as the mean±SD. aobtained by dividing its original parameter by body-weight normalized dosage.