Figure 2.

A single injection of α5IA produces a long‐term restoration of recognition memory deficits in Ts65Dn mice in the novel object recognition (NOR) task. (a) Schematic diagram of the NOR test. (b) Mean distance travelled per minute during the three sessions of the NOR (habituation, acquisition, and test). Results are shown as Cumming estimation plots. Raw data are plotted in the upper panels. Mean differences are plotted on the middle panel (treatment) and the lower panel (genotype). We calculated the 95% confidence interval of the mean difference (ends of the vertical error bars) by performing bootstrap resampling. Ts65Dn mice were hyperactive during all sessions as shown by the increase of the mean distance travelled per minute, and α5IA significantly decreased this hyperactivity during the test session. (c) Recognition index (time spent exploring the novel object over the total time spent exploring both familiar and novel objects) during the test session and statistical analyses. α5IA restored memory defects of Ts65Dn mice 5 days after treatment. ^* P < .05, significantly different as indicated