Figure 3.

A single injection of α5IA produces a long‐term restoration of spatial working memory deficits in Ts65Dn mice in the Y‐maze task. (a) Schematic diagram of the Y‐maze test with the three types of visual cues in the three arms. (b) Number of arms visited in the Y‐maze session. Results are shown as Cumming estimation plots. Raw data are plotted on the upper panels. Mean differences are plotted on the middle panel (treatment) and the lower panel (genotype). We calculated the 95% confidence interval of the mean difference (ends of the vertical error bars). (c) Spontaneous alternation in the Y maze. Results are shown as mean ± SEM. We calculated the 95% confidence interval of the mean difference by performing bootstrap resampling. Working memory deficits in Ts65Dn mice were reversed 6 days after a single injection of α5IA. ^* P < .05, significantly different as indicated