Figure 5.

The anti‐TT IgG titre over time (pre‐ and post‐treatment) for animals treated with vehicle (a) N = 30 pre‐treatment, N = 18 post‐treatment, i.v. VIB4920 (b) for vehicle and 300 mg·kg⁻¹ N = 18 pre‐treatment and N = 9 post‐treatment, for 150 mg·kg⁻¹ dose group N = 18 pre‐treatment and N = 6 post‐treatment, and s.c. VIB4920 (c) N = 18 pre‐treatment, N = 0 post‐treatment in all three studies. TT immunisation was given on pre‐study Day −28 and following VIB4920 washout on Day 136 (Studies 1 and 2) or 351 (Study 3). Treatment with VIB4920 did not have a long‐term effect on the immune response as the secondary TT response was restored after VIB4920 washout. Two‐way ANOVA repeated measures model (with Greehouse–Geisser correction) followed by Dunnetts multiple comparisons test. IgG, immunoglobulin G; i.v., intravenous; s.c., subcutaneous; TT, tetanus toxoid