Skip to main content
. 2020 Jan 26;177(5):1164–1186. doi: 10.1111/bph.14910

Figure 7.

Figure 7

GoSlo‐SR‐5‐6‐induced relaxations of isometric tone are reduced when Kv7 channels are blocked. (a) Example of the effect of XE991 on relaxation induced by 10−5 M GoSlo‐SR‐5‐6. Application denotes the time point where GoSlo‐SR or vehicle was added; (b) effect of 10−5 M GoSlo‐SR‐5‐6 on methoxamine (MX)‐induced contraction. Vessel tension in the absence (DMSO–con) and presence of GoSlo‐SR‐5‐6 (GoSlo–con) and of GoSlo‐SR‐5‐6 together with 3 × 10−6 M XE991 (GoSlo–XE991; repeated measures ANOVA: GoSlo‐SR‐5‐6 vs. GoSlo‐SR‐5‐6 + XE991: n = 9; P < .05); (c) effect of 10−5 M GoSlo‐SR‐5‐6 on MX‐induced contraction. Vessel tension in the absence (DMSO–con) and presence of GoSlo‐SR‐5‐6 (GoSlo–con) and of GoSlo‐SR‐5‐6 together with 10−5 M XE991 (GoSlo–XE991; repeated measures ANOVA: GoSlo‐SR‐5‐6 vs. GoSlo‐SR‐5‐6 + XE991: n = 7; P < .05; repeated measures ANOVA: GoSlo‐SR‐5‐6 + 3 × 10−6 M XE991 vs. GoSlo‐SR‐5‐6 + 10−5 M XE991: P = .72); (d) effect of 10−5 M GoSlo‐SR‐5‐6 on MX‐induced contraction. Vessel tension in the absence (DMSO–con) and presence of GoSlo‐SR‐5‐6 (GoSlo–con) and of GoSlo‐SR‐5‐6 together with 10−5 M linopirdine (GoSlo–Lino; repeated measures ANOVA: GoSlo‐SR‐5‐6 vs. GoSlo‐SR‐5‐6 + Lino: n = 9; P < .05); (e) effect of 10−5 M GoSlo‐SR‐5‐6 on MX‐induced contraction. Vessel tension in the absence (DMSO–con) and presence of GoSlo‐SR‐5‐6 (GoSlo–con) and of GoSlo‐SR‐5‐6 together with 3 × 10−6 M XE991, 10−6 M DPO‐1, and 10−7 M stromatoxin (GoSlo–XE991 + DPO‐1 + STX; repeated measures ANOVA: GoSlo‐SR‐5‐6 vs. GoSlo‐SR‐5‐6 + XE991 + DPO‐1 + STX: n = 10; P < .05; repeated measures ANOVA: GoSlo‐SR‐5‐6 + 3 × 10−6 M XE991 vs. GoSlo‐SR‐5‐6 + XE991 + DPO‐1 + STX: P = .25)