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. 2020 Jan 26;177(5):1164–1186. doi: 10.1111/bph.14910

Figure 8.

Figure 8

Contribution of BK and Kv7 channels to the effect of GoSlo‐SR. (a) Example of the effect of IBTX and XE991 on relaxation induced by 10−5 M GoSlo‐SR‐5‐6. The arrows with the label (IBTX + XE991 + MX) denote the time points where pre‐constriction was initiated by the addition of IBTX, XE991 and methoxamine (MX). The arrow with the label (GoSlo/DMSO) denotes the time point where GoSlo‐SR‐5‐6 or vehicle (DMSO) was added; (b) example of the effect of IBTX and XE991 on relaxation induced by 10−5 M GoSlo‐SR‐5‐130. The arrows with the label (IBTX + XE991 + MX) denote the time points where pre‐constriction was initiated by the addition of IBTX, XE991, and MX. The arrow with the label (GoSlo/DMSO) denotes the time point where GoSlo‐SR‐5‐130 or vehicle (DMSO) was added; (c) effect of 10−5 M GoSlo‐SR‐5‐6 on MX‐induced contraction. Vessel tension in the presence of 10−7 M IBTX and 3 × 10−6 M XE991 in the absence (DMSO) and presence of GoSlo‐SR‐5‐6 (GoSlo; repeated measures ANOVA: n = 8; P = .98); (d) effect of 10−5 M GoSlo‐SR‐5‐130 on MX‐induced contraction. Vessel tension in the presence of 10−7 M IBTX and 3 × 10−6 M XE991 in the absence (DMSO) and presence of GoSlo‐SR‐5‐130 (GoSlo; repeated measures ANOVA: n = 6; P = .78); (e) effect of 10−5 M GoSlo‐SR‐5‐6 on MX‐induced contraction. Vessel tension in the absence (con) and presence of 10−7 M IBTX and 10−6 M DPO‐1 (IBTX + DPO; repeated measures ANOVA: n = 10; P = .43); (f) effect of 10−5 M GoSlo‐SR‐5‐6 on MX‐induced contraction. Vessel tension in the absence (con) and presence of 10−7 M IBTX and 10−7 M stromatoxin (IBTX + STX; repeated measures ANOVA: n = 7; P = .95)