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. 2020 Jan 26;177(5):1164–1186. doi: 10.1111/bph.14910

Figure 10.

Figure 10

GoSlo‐SR‐5‐6 also causes relaxation of saphenous arteries. (a) Effect of 10−5 M GoSlo‐SR‐5‐6 on MX‐induced contraction. Vessel tension in the presence of GoSlo‐SR‐5‐6 (GoSlo–con), in the presence of GoSlo‐SR‐5‐6 and 10−7 M IBTX (GoSlo–IBTX), and in the presence of the vehicle of GoSlo‐SR and IBTX (DMSO–IBTX). (repeated measures ANOVA: GoSlo‐SR‐5‐6–IBTX vs. DMSO–IBTX: n = 6; P < .05; GoSlo‐SR‐5‐6–con vs. GoSlo‐SR‐5‐6–IBTX: n = 6; P = .55); (b) effect of 10−5 M GoSlo‐SR‐5‐6 on MX‐induced contraction. Vessel tension in the presence of GoSlo‐SR‐5‐6 (GoSlo–con), in the presence of GoSlo‐SR‐5‐6 and 3 × 10−6 M XE991 (GoSlo–XE), and in the presence of the vehicle of GoSlo‐SR and XE991 (DMSO–XE). (repeated measures ANOVA: GoSlo‐SR‐5‐6–XE vs. DMSO–XE: n = 7; P < .05; GoSlo‐SR‐5‐6–con vs. GoSlo‐SR‐5‐6–XE: n = 7; P < .05); (c) effect of 10−5 M GoSlo‐SR‐5‐6 on MX‐induced contraction. Vessel tension in the presence of GoSlo‐SR‐5‐6 and 10−7 M IBTX together with 3 × 10−6 M XE991 (GoSlo–IBTX + XE), and in the presence of the vehicle of GoSlo‐SR and IBTX together with XE991 (DMSO–IBTX + XE). (repeated measures ANOVA: GoSlo‐SR‐5‐6–IBTX + XE vs. DMSO–IBTX + XE: n = 7; P = .78)