Figure 13.
GoSlo‐SR‐5‐6 causes hyperpolarisation of isometric preparations of rat mesenteric arteries. (a) Example of the effect of 3 × 10−6 M GoSlo‐SR‐5‐6 on membrane potential (upper trace) and contractile force (lower trace) of an isometric vessel preparation at 10−6 M methoxamine (MX)‐induced tone and after subsequent application of 3 × 10−6 M XE991. The microelectrode symbol denotes phases when the microelectrode was impaled/not impaled. Summarised data of membrane potential (b) and contractile force (c) in the presence of 10−6 M MX, MX + 3 × 10−6 M GoSlo‐SR‐5‐6, and MX + GoSlo‐SR‐5‐6 + 3 × 10−6 M XE991. (*repeated measures ANOVA: MX vs. MX–GoSlo‐SR‐5‐6(n = 7); P < .05; MX–GoSlo‐SR‐5‐6 vs. MX–GoSlo‐SR‐5‐6–XE(n = 6); P < .05, Bonferroni's multiple comparison test)