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. 2020 Feb 19;8:83. doi: 10.3389/fcell.2020.00083

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Copyright © 2020 Jia, Rao, Miu, Tang, Chen, Yang, Li, Li, Chen and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in static parameters of cortical bone with or without Alendronate treatment in pregnant mice. (A) Horizontal cross-section of TX. The outer layer is cortical bone while the inner core is bone marrow. (a–c) Representative images from different animals in the same treatment group. (B–F) Static parameters of tibia diaphysis. *P < 0.05, **P < 0.01 (T.Ar, Total tissue area; Ct.Ar, cortical bone area; Ma.Ar, marrow area; %Ma.Ar, percentage of medullary area; %Ct.Ar, percentage of cortical bone area).