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. 2020 Feb 19;8:83. doi: 10.3389/fcell.2020.00083

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Copyright © 2020 Jia, Rao, Miu, Tang, Chen, Yang, Li, Li, Chen and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in dynamic parameters of cortical bone with or without Alendronate treatment in pregnant mice. (A) Fluorescent image indicating horizontal cross-section of TX. Panel (zoom) is the zoom-in image of (b) while the red arrows indicated the positions of double calcein fluorescence label. (a–c) Representative images from different animals in the same treatment group. (B–H) Dynamic parameters of tibia diaphysis. *P < 0.05, **P < 0.01, ***P < 0.001 (%P-L.Pm, periosteal labeled perimeter; %E-L.Pm, endosteal labeled perimeter; E-BFR/BS, endosteal bone formation rate; E-MAR, endosteal MAR; P-BFR/BS, periosteal bone formation rate; P-MAR, periosteal MAR; E-%E.Pm, endosteal bone absorption).