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. 2020 Feb 19;8:83. doi: 10.3389/fcell.2020.00083

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Copyright © 2020 Jia, Rao, Miu, Tang, Chen, Yang, Li, Li, Chen and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fetal skeleton examination and maternal serum bone turnover biomarker levels. (A) The whole skeleton staining of fetal rats, red region stained for calcified bone structure, and blue region stained for cartilages. (B) The graph shows the average length of representative fetal bone structures in Pregnant group (n = 83, 10 l) and Alendronate group (n = 77, 10 l). (C–E) Bar-chart reporting serum levels of biomarker for bone turnover. (C) Osteocalcin and (D) PINP for bone formation and (E) Pyridinium for bone resorption, respectively. ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001. PINP, type I collagen amino-terminal propeptide.