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. 2020 Feb 25;10:3353. doi: 10.1038/s41598-020-60334-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Neural correlates of candidate miRNA expression profile in PTSD. (a) Anatomical localization of the prefrontolimbic regions that were predefined as ROIs in this study. Mean CBF (upper panel) and GM volumes (lower panel) in the prefrontolimbic ROIs for each PTSD and control group are overlaid on the axial planes of the standard Montreal Neurological Institute template. (b) Scatterplots and regression lines to show the association of standardized values of miRNA expression for composite marker 1 with the ratio of CBF and GM volume between prefrontal and limbic regions of the brain, respectively. (c) Scatterplots and regression lines to show the association of standardized values of miRNA expression for composite marker 2 with the ratio of CBF and GM volume between prefrontal and limbic regions of the brain, respectively. P values in the scatter plots indicate 5,000 permutation-adjusted values. miRNA microRNA, PTSD posttraumatic stress disorder, ROIs regions-of-interest, CBF cerebral blood flow, GM gray matter, L left, R right.