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. 2020 Feb 25;10:3422. doi: 10.1038/s41598-020-60241-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Proposed model for the Ribosome-associated quality control (RQC) pathway in mammals. A stalled ribosome collides with the following ribosome, and ZNF598 ubiquitinates the collided ribosomes. In yeast, it was proposed that the RQT complex dissociates the ubiquitinated ribosome(s) into subunits but the complex that recognizes and splits ubiquitinated ribosome(s) is unknown in mammals. Nascent peptide on the 60S subunit is ubiquitinated by Listerin, and released from the ribosome by ANKZF1 and p97. Then, the ubiquitinated polypeptides are degraded by the proteasome.