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. 2020 Feb 25;10:3386. doi: 10.1038/s41598-020-60053-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic diagram showing the changes in the levels and expression of enzymes involved in the glycolytic and fatty acid pathways in ibuprofen treated male and female mice livers. Abbreviations: PFK-1 (Phosphofructokinases-1); PKLR (pyruvate kinase, liver and RBC); FAS (Fatty acid synthase); LFABP (Liver Fatty acid-binding protein); FAAH (fatty acid amide hydrolase); CROT(carnitine O-octanoyltransferase); CYP4A1(Cytochrome P450 4A1), ATP(Adenosine triphosphate); CYP1A2 (Cytochrome P450 1A2); TCA (tricarboxylic acid cycle).