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. 2020 Feb 25;10:3384. doi: 10.1038/s41598-020-60450-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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A non-human primate model of tuberculosis. (A) Cynomolgus macaques were pre-treated with saline (n = 10) or BCG (n = 10) and challenged by Mtb. After the collection of blood samples at 0, 2, 4, 6, 8 weeks after Mtb challenge, monkeys were sacrificed for analysis at 12 weeks. (B) Bacterial burden of organs in macaques with or without BCG pretreatment at 12 weeks after Mtb challenge. Indicated organs were harvested 12 weeks after Mtb infection. Live Mtb counts (CFU) in organs were determined by the mycobacterial culture of organ homogenates. Bars represent mean ± SEM. *p < 0.05, by Mann-Whitney’s U test. (C) Immunohistochemical analysis of LRG. Paraffin sections of lung tissues obtained from Mtb-unchallenged (Mtb−) and Mtb-challenged (Mtb+) macaques were used for immunohistochemical analysis to visualize LRG protein expression in tuberculosis lesions.