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. 2020 Feb 25;10:3384. doi: 10.1038/s41598-020-60450-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Time-course analysis of inflammatory biomarkers in macaques with Mtb infection. (A,B) Mean values of biomarkers for the saline-treated and BCG-treated groups. Blood samples were harvested from cynomolgus macaques challenged by Mtb as indicated in Fig. 1A (n = 10 each for the saline group and the BCG group). Levels of ESR and CRP in these macaques were determined by laboratory tests (A). LRG levels were determined by ELISA (B). Data were shown as mean ± SEM. *p < 0.05 by a Sidak test. (C) Values of biomarkers for each macaque. Laboratory data of each monkey from the saline group (n = 10) and the BCG group (n = 10) was shown separately. (D) IL-6 levels in plasma collected at 0, 4, 8, 12 weeks after Mtb challenge. Plasma IL-6 levels were determined by a bead-based immunoassay. Data were shown as mean ± SEM. *p < 0.01 by Scheffe’s test. (E) Number of TB macaques with elevated levels of LRG or CRP. Cutoff values of LRG (7.80 μg/mL) and CRP (0.147 mg/dL) were defined as the mean + 1.96 SD of uninfected cynomolgus macaques.