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. 2020 Feb 25;10:3384. doi: 10.1038/s41598-020-60450-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Diagnostic performance of inflammatory biomarkers for active tuberculosis in macaques. Receiver operating characteristic (ROC) curve analyses for ESR, CRP and LRG in discrimination of active TB at 12 weeks after Mtb challenge were performed on the saline-treated macaques (A), BCG-treated macaques (B) and all macaques (C). The value of area under the ROC curve (AUC) of each biomarker is shown in the figure. Optimal cutoff values for ESR (2 mm/hr), CRP (0.14 mg/dL) and LRG (8.22 μg/mL) were determined by the ROC curve analysis of all macaques (C) and were used to calculate sensitivity, specificity, positive predictive value and negative predictive value of each biomarker.