Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 25;10:3402. doi: 10.1038/s41598-020-60258-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Preservation of the modular brain network organisation across baseline and two stages of propofol-induced sedation. Based on the consensus partitioning of individual brain graphs across the chosen cost densities (16 to 50% in 2% increments), between three to four broad communities were identified in all three experimental conditions (panel A). The corresponding Alluvial diagram shows the flow in the consensus community affiliations of 258 regions of interest (ROIs) from a previously introduced parcellation scheme (Power et al.⁶¹) across baseline resting state, as well as light and moderate propofol-induced sedation conditions. Modularity index (Q) and participation coefficient (P) did not show statistically significant alterations across experimental conditions (panels B,E) and across the chosen range of cost densities (panels C,F). Bars represent the standard error with the distribution of individual values provided for each measurement across each experimental condition. Notably, there was a significant correlation between the change in modularity index (Q) (r = 0.44, p = 0.029; panel D) as well as the change in participation coefficient (P) (r = −0.50, p = 0.014; panel G) and blood plasma propofol concentration when comparing the two propofol-induced sedation conditions at the percolation threshold (16% cost density). While straight lines indicate the linear fit, dotted lines represent the 95% confidence intervals.