Table 2.

Selection of top covariates using the Cox multivariable regression.

	Univariable analysis		Multivariable analysis
	HR (95% CI)	P-value	HR (95% CI)	P-value
Albumin <35 g/L	1.96 (1.66–2.31)	<0.001	1.26 (1.05–1.51)	0.015
Platelet count, × 109/La	1.68 (1.45–1.94)	<0.001	1.21 (1.04–1.40)	0.011
Diabetes	1.63 (1.34–1.99)	<0.001	1.41 (1.15–1.72)	0.001
HBsAg	0.82 (0.72–0.93)	0.002	0.79 (0.69–0.90)	0.001
Cholelithiasis	1.57 (1.28–1.92)	<0.001	1.40 (1.13–1.73)	0.002
AFP >50 ng/ml	1.49 (1.19–1.86)	0.001	1.60 (1.26–2.02)	<0.001
CA19–9 > 37 U/ml	1.49 (1.32–1.69)	<0.001	1.18 (1.03–1.37)	0.020
CEA, ng/mlb	1.37 (1.27–1.47)	<0.001	1.12 (1.03–1.22)	0.011
Tumor size, cmc	1.69 (1.56–1.84)	<0.001	1.59 (1.46–1.73)	<0.001
Tumor numberd	1.51 (1.37–1.67)	<0.001	1.28 (1.15–1.42)	<0.001
Lymph node metastasis	1.93 (1.68–2.22)	<0.001	1.40 (1.21–1.63)	<0.001
Resection typee	1.57 (1.42–1.74)	<0.001	1.17 (1.05–1.31)	0.005

HR, hazard ratio; CI, confidence interval; HBsAg, hepatitis B surface antigen; AFP, alpha fetoprotein; CA, carbohydrate antigen; CEA, carcinoembryonic antigen.

^awas stratified into <100, 100–300, and >300.

^bwas stratified into <2.5, 2.5–5.0, and >5.0.

^cwas stratified into ≤ 2.0, 2.1–3.0, 3.1–5.0, and >5.0.

^dwas stratified into single, double, and multiple.

^ewas stratified into minor hepatectomy, hemihepatectomy, and extended hepatectomy.