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. 2020 Feb 24;14:177–183. doi: 10.1016/j.reth.2020.02.002

Fig. 3.

Fig. 3

The mRNA expressions of baicalein-treated chondrocytes. IL-1β exposure significantly up-regulated the mRNA expressions of iNOS, IL-1β, TNF-α, IL-6, IL-8, MMP-3, MMP-9, MMP-13, Ki-67, COL1A1 and down-regulated AGCN, COL2A1 to chondrocytes relative to those of control group. Baicalein application significantly down-regulated the mRNA expression of IL-1β, TNF-α, MMP-3, MMP-9, Ki-67 and up-regulated IL-10, AGCN, COL2A1 when compared with those of IL-1β-stimulated cells. However, baicalein did not change iNOS, IL-6, IL-8, TIMP-1, COL1A1 and Sirt1 levels in treated chondrocytes.