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In vivo antitumor efficiency of different treatment groups in H22 tumor-bearing mice. KM mice were injected with saline, GTN, TPGS, TNO3, DOX, and DOX&TNO3 on alternate days. Tumor volume (A); relative body weight of tumor-bearing mice (B); tumor weight of tumor-bearing mice (C); images of tumor tissues (D). Data was presented as mean ± SD (n = 6). *: P 〈 0.05. **: P < 0.01. ***: P 〉 0.05. (Reproduced with permission from [29]. Copyright 2014 American Chemical Society).
