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ESR1 mutations in plasma from 54 patients with MBC detected by MB-NGS.
Plasma DNA from 54 patients with MBC was analyzed by MB-NGS for ESR1-LBD (gray box). Seventeen mutations were detected in 13 patients and indicated by lollipops, including one A312V, one S463P, two L536H, one L536P, one Y537C, seven Y537S, and four D538G mutations. AF-1/2, activation function-1/2; DBD, DNA binding domain; LBD, ligand-binding domain.
