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The dehydrogenase domain of NOX5 as model system for inhibition studies. (A) The dehydrogenase active site. Trp695 (green) is the stabilising amino acid belonging to the extension PWLEL added to the C-terminus (PDB 5O0X). (B) Inhibition studies (100 μM inhibitors) on the wild-type and C-terminal mutant dehydrogenase. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
