. 2020 Jan 2;106(1):71–91. doi: 10.1016/j.ajhg.2019.11.015

Table 2.

Transcriptome-wide Average GxEMM Heritability Estimates under the Hom ( $h_{g}^{2}$ ), IID ( $h_{I I D}^{2}$ ), and Free Models ( $h_{B P D}^{2}$ , $h_{S C Z}^{2}$ , $h_{C T R L}^{2}$ )

	$h_{g}^{2}$	$h_{I I D}^{2}$	$h_{B P D}^{2}$	$h_{S C Z}^{2}$	$h_{C T R L}^{2}$
Mean (%)	4.06	4.12	4.32	4.34	3.82
SE (%)	0.07	0.07	0.08	0.08	0.07
Wald p for $h^{2} > 0$	<2 × 10⁻¹⁶	<2 × 10⁻¹⁶	<2 × 10⁻¹⁶	<2 × 10⁻¹⁶	<2 × 10⁻¹⁶
Wald p for $h^{2} > h_{g}^{2}$	–	1.15 × 10⁻¹¹	1.93 × 10⁻⁹	<2 × 10⁻¹⁶	1.00
Wald p for $h^{2} > h_{I I D}^{2}$	–	–	3.83 × 10⁻⁶	<2 × 10⁻¹⁶	1.00

Because N is modest, we fit GxEMM with HE regression. We compare the models using Wald tests, estimating the standard errors of the transcriptome-wide averages assuming independence across genes. Dash (–) indicates that the comparison is not meaningful.