Table 1.
The effects of L-norvaline on some blood and urine components in hypertensive (ISIAH) and normotensive (Wistar) rats on the seventh treatment day. Values are expressed as the mean ± SEM, ∗p < 0.05.
| Rat strain | ISIAH | Wistar | ||
|---|---|---|---|---|
| Type of treatment | Control | Norvaline | Control | Norvaline |
| Creatinine in urine mmol/l | 7,35 ± 0,51 | 5,39 ± 0,56∗ | 5,87 ± 0,98 | 10,08 ± 1,13∗ |
| Creatinine excretion μmol/day | 95 ± 6,0 | 102 ± 9,5 | 92 ± 2,6 | 92 ± 5,1 |
| Creatinine in plasma μmol/l | 42,4 ± 2,5 | 38,8 ± 1,4 | 37,2 ± 2,3 | 37,1 ± 1,7 |
| Glomerular filtration rate ml/min per 100 g body mass | 0,42 ± 0,05 | 0,42 ± 0,047 | 0,48 ± 0,036 | 0,48 ± 0,02 |
| Uric acid in urine μmol/l | 496 ± 67 | 671 ± 49 | 450 ± 91 | 449 ± 41 |
| Uric acid in plasma μmol/l | 34,6 ± 7,4 | 33,8 ± 1.3 | 36,6 ± 2,7 | 41,6 ± 8,3 |
| UN in urine mmol/l | 971 ± 4,3 | 706 ± 98,3 | 919 ± 219,6 | 1391 ± 111 |
| UN in plasma mmol/l | 6,79 ± 0,29 | 6,8 ± 0,49 | 5,97 ± 0,57 | 5,29 ± 0,48 |
| Urea in urine mmol/l | 1031 ± 48,1 | 825 ± 81,1∗ | 840 ± 179,7 | 1269,2 ± 68,5∗ |
| Urea excretion mmol/day | 13,63 ± 1,24 | 17,0 ± 2,05 | 12,5 ± 1,15 | 12,1 ± 1,15 |
| Urea in plasma mmol/l | 7,04 ± 0,33 | 7,18 ± 1,13 | 6,24 ± 0,59 | 6,52 ± 0,92 |