Table 1.

Adverse Drug Reaction Probability Scale.

Question	Yes	No	Do not know	Ibrutinib	Cetuximab
1. Are there previous conclusive reports on this reaction?	+1	0	0	1	1
2. Did the adverse event appear after the suspected drug was administered?	+2	-1	0	2	2
3. Did the adverse event improve when the drug was discontinued or a specific antagonist was administered?	+1	0	0	1	0
4. Did the adverse event reappear when the drug was readministered?	+2	-1	0	2	-1
5. Are there alternative causes that could on their own have caused the reaction?	-1	+2	0	-1	-1
6. Did the reaction reappear when a placebo was given?	-1	+1	0	0	0
7. Was the drug detected in blood or other fluids in concentrations known to be toxic?	+1	0	0	0	0
8. Was the reaction more severe when the dose was increased or less severe when the dose was decreased?	+1	0	0	1	1
9. Did the patient have a similar reaction to the same or similar drugs in any previous exposure?	+1	0	0	0	0
10. Was the adverse event confirmed by any objective evidence?	+1	0	0	1	1
			Total	7	3