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. 2020 Feb 14;2020:3645157. doi: 10.1155/2020/3645157

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Copyright © 2020 Wenhua Xu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Quantitative analysis of CTLA-4 mRNA in Treg cells from myasthenia gravis patients (MG) and healthy donors (HD). (a) Total RNA was extracted from sorted Treg cells of MG and HD and then real-time PCR was performed to measure CTLA-4 mRNA level. (b) Genomic DNA was prepared from sorted Treg cells and methylation status within CTLA-4 promoter was detected. The methylation percentage within CTLA-4 promoter in Treg cells from HD and MG (n = 10) was shown. (c) The methylation percentage at -658 and -793 CpGs in Treg cells from MG and MG with IVIg therapy (n = 12) is shown. Data are expressed as mean ± SD. ^∗P < 0.05.