Table 1.

Enrollment criteria.

Inclusion criteria	Exclusion criteria
Presence of chronic wounds at least 4-week duration	Pregnancy and lactation period
	Concomitant malignancy
Chronic wound arrested in an inflammatory stage	Concomitant chronic diseases in the decompensation stage
18 to 90 years old	Patients in terminal state
Voluntary informed consent	2-year alcoholism or drug addiction prior to the enrollment in the study
	Sepsis, septicopyemia
	Persistence anaerobic infection in the wound