Table 1.
Characteristics of Cases and Controls in the Study Cohort
| Characteristics | Cases (n=12,099) No. (%) |
Controls (n=118,467) No. (%) |
|---|---|---|
| Sex | ||
| Men | 5985 (49.5) | 58,269 (49.2) |
| Women | 6114 (50.5) | 60,198 (50.8) |
| Age at Diagnosis/Index Date, Years | ||
| <50 | 3160 (26.1) | 30,319 (25.6) |
| 50–69 | 5615 (46.4) | 55,236 (46.6) |
| ≥70 | 3324 (27.5) | 32,912 (27.8) |
| Residential Ambient UVRa Exposure | ||
| Low (northern Norway) | 716 (5.9) | 11,895 (10.0) |
| Medium (central/western Norway) | 1724 (14.3) | 19,429 (16.4) |
| Highest (southern/eastern Norway) | 9659 (79.8) | 87,143 (73.6) |
| Parity (Women Only) | ||
| No children | 1861 (30.4) | 18,984 (31.5) |
| 1–3 children | 3894 (63.7) | 36,901 (61.3) |
| >3 children | 359 (5.9) | 4313 (7.2) |
| Tumor Site | ||
| Head/neck | 1314 (10.9) | - |
| Trunk | 5657 (46.7) | - |
| Upper limb | 1559 (12.9) | - |
| Lower limb | 2867 (23.7) | - |
| Other sites | 52 (0.4) | - |
| Unspecified site | 650 (5.4) | - |
| Histological Type | ||
| Superficial spreading melanoma | 6654 (55.0) | - |
| Nodular melanoma | 2076 (17.2) | - |
| Other | 3369 (27.8) | - |
| Clinical Stage | ||
| Local disease | 9828 (81.2) | - |
| Regional metastasis | 572 (4.7) | - |
| Distant metastasis | 635 (5.3) | - |
| Unspecified | 1064 (8.8) | - |
| Use of Antidepressants | ||
| I. Number of Prescriptions | ||
| ≤1 | 10,597 (87.6) | 102,154 (86.2) |
| 2–7 | 663 (5.5) | 6612 (5.6) |
| ≥8 | 839 (6.9) | 9701 (8.2) |
| II. By Antidepressant Classes | ||
| Non-userb | 10,185 (84.2) | 97,823 (82.6) |
| SSRIc | 699 (5.8) | 7358 (6.2) |
| TCAd | 375 (3.1) | 3749 (3.2) |
| Othere | 317 (2.6) | 3486 (2.9) |
| Mixedf | 523 (4.3) | 6051 (5.1) |
| III. By Cumulative Dose, DDDg | ||
| 0 | 10,185 (84.2) | 97,823 (82.6) |
| 1–91 | 524 (4.3) | 5630 (4.8) |
| 92–365 | 454 (3.8) | 4764 (4.0) |
| 366–1460 | 508 (4.2) | 5239 (4.4) |
| ≥1461 | 428 (3.5) | 5011 (4.2) |
| Ever Use of Other Drugs | ||
| Immunosuppressant drugsh | 1862 (15.4) | 18,511 (15.6) |
| Cardiovascular drugsh | 5951 (49.2) | 57,264 (48.3) |
| Other drugsi | 5379 (44.5) | 53,033 (44.8) |
Notes: aUltraviolet radiation; b0 prescription; cSelective serotonin reuptake inhibitors (N06AB); dTricyclic antidepressants (N06AA); eOther antidepressants (N06AF, N06AG and N06AX); fUse of more than one class of antidepressants; gDefined daily dose; hIncludes mixed use with other drugs; iIncludes use of other drugs than immunosuppressant or cardiovascular drugs.