Table 2.
Rate Ratios (RRs) with 95% Confidence Intervals (CIs) for Melanoma Incidence by Number of Prescriptions of Antidepressants Overall and Stratified by Class of Antidepressants
| Number of Prescriptions | No. Case/Controls | RR (95% CI)a | Ptrendf |
|---|---|---|---|
| Overall | |||
| ≤1 | 10,597/102,154 | 1.00 (reference) | |
| 2–7 | 663/6612 | 0.94 (0.87, 1.03) | |
| ≥8 | 839/9701 | 0.81 (0.75, 0.87) | <0.001 |
| By Antidepressant Classes | |||
| SSRIb | |||
| ≤1 | 4736/45,455 | 1.00 (reference) | |
| ≥8 | 289/3280 | 0.82 (0.73, 0.93) | 0.003 |
| TCAc | |||
| ≤1 | 2782/26,637 | 1.00 (reference) | |
| ≥8 | 107/1100 | 0.90 (0.73, 1.10) | 0.295 |
| Otherd | |||
| ≤1 | 2679/25,576 | 1.00 (reference) | |
| ≥8 | 84/967 | 0.81 (0.65, 1.02) | 0.036 |
| Mixede | |||
| ≤1 | 3838/36,528 | 1.00 (reference) | |
| ≥8 | 359/4354 | 0.77 (0.69, 0.86) | <0.001 |
Notes: aAdjusted for sex and birth year (by design) and ever use of other drugs and residential ambient ultraviolet radiation; bSelective serotonin reuptake inhibitors (N06AB); cTricyclic antidepressants (N06AA); dOther antidepressants (N06AF, N06AG and N06AX); e Use of more than one class of antidepressants; fTrend test uses the median number of prescriptions for all prescription categories (≤1; 2−7; ≥8).