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. 2019 Dec 11;5(1):122–131. doi: 10.1002/lio2.336

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© 2019 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals, Inc. on behalf of The Triological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Hybrid ear cube. The hybrid ear cube is a silicone‐based implant that consists of a cuboid portion placed in the middle ear adjacent to the oval window (shown) or round window and a cylindrical structure that passes through the oval window or round window that remains in contact with the perilymph.93 The cuboid structure has two halves that can be loaded with two different drug formulations and acts as a drug reservoir such that drugs can diffuse through the cylindrical portion into the perilymph. Reprinted from European Journal of Pharmaceutical Sciences, Volume 126, Gehrke et al., Hybrid Ear Cubes for local controlled dexamethasone delivery to the inner ear, pages 23‐32, 2019, with permission from Elsevier