Table 1.

Recommended tests for patients with T-PLL

Assessments	General practice	Trials
To establish diagnosis
History, physical examination	Always	Always
Blood count and differential count	Always	Always
Bone marrow aspirate and biopsy	When clinically indicated	Desirable
Biopsy or aspirate of suspected involved site	When clinically indicated	Desirable
Immunophenotyping of blood lymphocytes	Always	Always
T-cell receptor rearrangement (TRB, TRG)	Always	Always
chromosome banding analysis	Desirable	Desirable
Fluorescence in situ hybridization (FISH)	Desirable	Desirable
Testing for HTLV	Always*	Always*
Before treatment start and at response assessment
CIRS,† physical examination, performance status	Always	Always
Blood count and differential count	Always	Always
Bone marrow aspirate and biopsy‡	Always	Always
Serum chemistry	Always	Always
Infectious disease status (HBV, HCV, HIV, HSV)†	Always	Always
Serum lactate dehydrogenase	Always	Always
b2-microglobulin	Desirable	Always
CT scan of neck, chest, abdomen, pelvis	Always	Always
PET scans	Not generally indicated	Not generally indicated
Chest radiograph	Not generally indicated	Not generally indicated
Abdominal ultrasound	Not generally indicated	Not generally indicated
Next-generation sequencing, MRD	Not generally indicated	Desirable

CIRC, cumulative illness rating scale; HBV, hepatitis B virus; HCV, hepatitis C virus; HSC, herpes simplex viruses; HTLV, human T-cell leukemia-lymphoma virus.

^*In patients from endemic countries.

^†Before treatment start.

^‡To confirm a remission.