Table 4.

Criteria for staging and indication of treatment in T-PLL

Staging: at least 1 criterion defines active T-PLL (= indication for treatment)
Disease-related constitutional symptoms	Significant fatigue: ECOG ≥2
	Unintentional weight loss of >10% of normal body weight in ≤6 mo
	Drenching night sweats, without evidence of infection
	Fever greater than 38°C, without evidence of infection
Symptomatic bone marrow failure	Hemoglobin	<10 g/dL
	Platelet count	<100 × 109/L
Rapidly enlarging lymph nodes, spleen, and liver	>50% in 2 mo; diameter doubling <6 mo
	Symptomatic enlarged lymph node, spleen, or liver
Increasing lymphocytosis	If >30 × 109/L: >50% in 2 mo; lymphocyte doubling time <6 mo
Extranodal involvement	Organ infiltration; peritoneal or pleural effusion, central nervous system involvement