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Pharmacokinetic profile of SAR405838 following a single oral administration. (A) Concentration-over-time in plasma, (B) concentration-over-time in brain, and (C) brain-to-plasma ratio over time in wild-type, Mdr1a/b–/–, Bcrp1–/–, and Mdr1a/b–/–Bcrp1–/– FVB mice. Data presented as mean ± S.D. where N = 3–5 for each time point.
