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The effect of a pharmacological inhibitor of efflux transport, elacridar, on the plasma and brain concentration of SAR405838. (A) Concentrations in plasma and brain at 2- and 6-hour postdose with coadministration of either vehicle control or inhibitor, either LY335979 or elacridar. (B) Brain-to-plasma ratio at 2- and 6-hour postdose. Data presented as mean ± S.D. where N = 3–5 for each group. **P < 0.01; ***P < 0.005.
