TABLE 5.
Pharmacokinetic parameters estimated from one-compartment model that describes the total concentration-time profile from each genotype following a single oral (25 mg/kg) administration
| Estimated Parameters | Mean | CV (%) | 95% C) |
|---|---|---|---|
| Vc (ml/kg) | 1166 | ** fixed ** | |
| Ke (h−1) | 0.269 | ** fixed ** | |
| Ka, WT (h−1) | 0.265 | 6.1 | (0.225, 0.304) |
| Ka, BKO (h−1) | 0.290 | 15.7 | (0.179, 0.401) |
| Ka, PKO (h−1) | 0.240 | 10.1 | (0.177, 0.302) |
| Ka, TKO (h−1) | 0.258 | 14.3 | (0.221, 0.460) |
BKO, Bcrp1−/−; Ka, absorption rate constant after oral dosing in different genotypes; Ke, elimination rate constant from the central compartment (obtained value from mean pooled analysis of all genotypes); PKO, Mdr1a/b−/−; TKO, Mdr1a/b−/−Bcrp1−/−; Vc, volume of distribution of a drug in the central compartment (obtained value from mean pooled analysis of all genotypes); WT, wild type.