Table 3. Hazard Ratios for ARIC and MESA Incident CHD Events for Selected Polygenic Risk Score Strata.
| Polygenic Risk Scores | Hazard Ratio (95% CI)a | |
|---|---|---|
| ARIC | MESA | |
| Continuous per SD increment | 1.24 (1.15-1.34) | 1.38 (1.21-1.58) |
| Top percentilesb | ||
| 20 | 1.54 (1.30-1.83) | 1.63 (1.22-2.19) |
| 10 | 1.68 (1.35-2.09) | 1.74 (1.21-2.51) |
| 5 | 1.68 (1.25-2.26) | 2.15 (1.37-3.37) |
| 2 | 2.04 (1.33-3.13) | 2.68 (1.41-5.06) |
Abbreviations: ARIC, Atherosclerosis Risk in Communities; CHD, coronary heart disease; MESA, Multi-Ethnic Study of Atherosclerosis.
a
Hazard ratios (95% CIs) are derived from a Cox proportional hazards regression adjusted for age, sex, and 5 principal components.
b
The hazard ratios are the risk of a CHD diagnosis for individuals in the top quantile of the distribution compared with individuals in the remaining sample.