Figure 3. Association Between the Predicted Polymethylation Score and Dorsolateral Prefrontal Cortex Hippocampal Connectivity in Healthy Controls Not Taking Medication.
A, In the validation methylation/magnetic resonance imaging (validation methylation/MRI) group (n-back task), uncorrected results (P < .05, shown in hippocampus) with peak voxel (F1,237 = 14.55; t237 = −3.81; Montreal Neurological Institute [MNI] coordinates: 33, −22, −13) in the right hippocampus that were significant after bilateral hippocampus correction in healthy participants (241 [10.8%]) (P for familywise error = .04). B, In the validation MRI group (Sternberg task): uncorrected results (P < .05, shown in hippocampus) with peak voxel (t148 = −3.54; peak voxel at 33, −37, −7 in the right hippocampus showing a significantly negative association after right posterior hippocampus correction in healthy participants (152 [6.8%]) (P for familywise error = .02). Age and sex were controlled as covariates of noninterest. For presentation purposes, imaging results are shown in P < .05 uncorrected threshold at a similar spatial plane (MNI: X = 32, Y = −33, and Z = −10).