Table 2. Prediction Performance of BioMM on Different Cohorts Using Discovery Methylation as the Discovery Set.

Data Sets	AUC	R2
Discovery methylation	0.78	0.21
Validation methylation	0.69	0.105
Validation methylation/MRI	0.74	0.218
Validation post mortem	0.63	0.083

Abbreviations: AUC, area under the receiver operating characteristic curve; BioMM, biologically informed machine learning; MRI, magnetic resonance imaging.