Figure 1. In-situ formation of precursor skin tissue using an intraoperative approach.

a, Schematic illustration of handheld approach for delivering cell-laden biomaterial sheets conformal to full-thickness burn wound of arbitrary size and topology. b, Rendered image of handheld instrument for controllable delivery of bioink consisting of mesenchymal stem/stromal cells (MSCs) in fibrin-based bioink (green color) supplied at flow rate Q_B with cross-linker (clear) supplied at flow rate Q_C through microfluidic printhead, while driven by soft wheel along wound surface at velocity V.