. 2020 Feb 24;174(5):1–9. doi: 10.1001/jamapediatrics.2019.6096

Table 4. Analysis of ART and Congenital Heart Defects Association With Twin Pregnancy as a Mediator^a.

Mediation Association	Estimate, Odds Ratio (95% CI)
Total	1.68 (1.44-1.92)
Natural direct	1.09 (0.93-1.25)
Natural indirect	1.55 (1.47-1.62)

Abbreviation: ART, assisted reproductive technology.

^{^a}

The proportion mediated was 87.3%. Exposure variable: ART; mediator: twin pregnancy; interaction: ART × twin pregnancy; and covariates: maternal age; parity; quintiles of median family income at the dissemination-area level; quintile of percentage of university degree at the dissemination-area level; prepregnancy obesity; maternal smoking, social drug use, or alcohol consumption; folic acid intake during pregnancy; all types of mental health illness during prepregnancy or pregnancy; and all types of prepregnancy maternal health conditions.

Table 4. Analysis of ART and Congenital Heart Defects Association With Twin Pregnancy as a Mediatora.

Table 4. Analysis of ART and Congenital Heart Defects Association With Twin Pregnancy as a Mediator^a.