Table 2.

Multivariate analysis for OS and LFS in 164 MDS patients who had cytogenetic data at diagnosis

Variable	OS, 95% CI				LFS, 95% CI
	HR	Lower	Upper	P	HR	Lower	Upper	P
Age*	1.024	1.007	1.040	.005	1.012	0.997	1.028	.114
IPSS-R†	1.418	1.116	1.803	.004	1.388	1.091	1.766	.008
ASXL1	1.277	0.684	2.386	.443	1.875	1.037	3.388	.037
SRSF2	0.766	0.372	1.579	.471	0.710	0.355	1.420	.333
TP53	3.108	1.254	7.702	.014	3.239	1.299	8.077	.012
ZRSR2	1.382	0.683	2.794	.368	1.023	0.508	2.060	.949
Higher LSC4 score‡	3.452	1.875	6.356	<.001	3.792	2.076	6.929	<.001

P < .05 is considered statistically significant. Only variables with P ≤ .05 in univariate analysis were incorporated into the multivariate Cox proportional hazard regression analysis.

CI, confidence interval; HR, hazard ratio.

^*Continuous variable.

^†IPSS-R risk groups: very good, good, intermediate, poor, and very poor.

^‡High vs low LSC4 risk scores (median as cutoff).