Table 1.
Characteristics of nephrectomized localized ccRCC patients included in analysis
| Cohorts |
||||
|---|---|---|---|---|
| Characteristic | Contemporary UK 2011-2014 n = 384 |
Historic UK 1998-2006 n = 191 |
Original Leibovich 1970-2000 n = 1671 |
|
| Age at procedure | Median (range) | 63 (29, 92) | 64 (29, 86) | 65 (24, 89) |
| Gender | Male | 252 (66) | 110 (58) | 1061 (64) |
| Female | 132 (34) | 81 (42) | 610 (36) | |
| Procedure†,‡,§ | PN | 100 (26) | 12 (6) | 0 (0) |
| RN | 284 (74) | 178 (93) | 1671 (100) | |
| Missing | 0 (0) | 1 (1) | 0 (0) | |
| Stage‡ | I | 227 (59) | 93 (49) | NA |
| II | 42 (11) | 13 (7) | NA | |
| III | 115 (30) | 85 (45) | NA | |
| Leibovich Score elements | ||||
| Tumor size (mm) | Median (range) | 50 (11, 180) | 55 (2, 160) | 65 (8, 240) |
| Tumor size†,§ | ≤10 cm | 350 (91) | 166 (87) | 1312 (78) |
| >10 cm | 34 (9) | 25 (13) | 359 (22) | |
| Grade†,§ | 1 | 6 (2) | 6 (3) | 182 (11) |
| 2 | 131 (34) | 61 (32) | 786 (47) | |
| 3 | 200 (52) | 94 (49) | 600 (36) | |
| 4 | 47 (12) | 30 (16) | 103 (6) | |
| pT*,†,‡,§ | 1a | 126 (33) | 45 (24) | 384 (23) |
| 1b | 102 (27) | 48 (25) | 440 (26) | |
| 2 | 42 (11) | 16 (8) | 335 (20) | |
| 3 | 114 (29) | 82 (43) | 507 (30) | |
| 4 | 0 (0) | 0 (0) | 5 (1) | |
| pN | 0/X | 376 (98) | 181 (95) | 1605 (96) |
| 1 | 8 (2) | 10 (5) | 56 (3) | |
| 2 | 0 (0) | 0 (0) | 10 (1) | |
| Necrosis | No | 282 (73) | 146 (76) | 1232 (74) |
| Yes | 102 (27) | 45 (24) | 439 (26) | |
| Leibovich risk group | ||||
| Low | 150 (39) | 60 (31) | 689 (41) | |
| Intermediate | 163 (42) | 86 (45) | 608 (36) | |
| High | 71 (19) | 45 (24) | 374 (22) | |
NA, not available; PN, partial nephrectomy; RN, radical nephrectomy.
⁎
AJCC 2002 TNM staging applied in original Leibovich and historic UK cohorts vs 2010 TNM staging applied to contemporary UK cohort.
†
P <.05 Leibovich vs contemporary UK cohort.
‡
P <.05 contemporary UK vs historic UK cohort.
§
P <.05 Leibovich vs historic UK cohort.